학술논문
Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival
Document Type
article
Author
Tatiana Cajuso; Päivi Sulo; Tomas Tanskanen; Riku Katainen; Aurora Taira; Ulrika A. Hänninen; Johanna Kondelin; Linda Forsström; Niko Välimäki; Mervi Aavikko; Eevi Kaasinen; Ari Ristimäki; Selja Koskensalo; Anna Lepistö; Laura Renkonen-Sinisalo; Toni Seppälä; Teijo Kuopio; Jan Böhm; Jukka-Pekka Mecklin; Outi Kilpivaara; Esa Pitkänen; Kimmo Palin; Lauri A. Aaltonen
Source
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Retrotransposons are usually dormant in healthy tissue, but become activated during malignancy. Here, in colorectal cancer, Cajuso et al. show that retrotransposon activity associates with clinical features of the disease.