학술논문
Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Circadian disruption is implicated in the development of different human cancers. Here the authors show that chronic circadian disruption, through continuous jet lag, only moderately affects primary tumour growth but promotes cancer-cell dissemination and metastasis in a mouse model of spontaneous mammary tumorigenesis.