학술논문
A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer
Document Type
article
Author
Tomoko Saito; Atsushi Niida; Ryutaro Uchi; Hidenari Hirata; Hisateru Komatsu; Shotaro Sakimura; Shuto Hayashi; Sho Nambara; Yosuke Kuroda; Shuhei Ito; Hidetoshi Eguchi; Takaaki Masuda; Keishi Sugimachi; Taro Tobo; Haruto Nishida; Tsutomu Daa; Kenichi Chiba; Yuichi Shiraishi; Tetsuichi Yoshizato; Masaaki Kodama; Tadayoshi Okimoto; Kazuhiro Mizukami; Ryo Ogawa; Kazuhisa Okamoto; Mitsutaka Shuto; Kensuke Fukuda; Yusuke Matsui; Teppei Shimamura; Takanori Hasegawa; Yuichiro Doki; Satoshi Nagayama; Kazutaka Yamada; Mamoru Kato; Tatsuhiro Shibata; Masaki Mori; Hiroyuki Aburatani; Kazunari Murakami; Yutaka Suzuki; Seishi Ogawa; Satoru Miyano; Koshi Mimori
Source
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Advanced colorectal cancers are characterised by intra-tumour heterogeneity dictated by neutral evolution. Here the authors analyse early colorectal tumours by whole-exome sequencing and find that Darwinian evolution determines the fate of early lesions in colorectal adenoma and carcinoma in situ.