학술논문
Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
Document Type
article
Author
Yanni Zeng; Carmen Amador; Charley Xia; Riccardo Marioni; Duncan Sproul; Rosie M. Walker; Stewart W. Morris; Andrew Bretherick; Oriol Canela-Xandri; Thibaud S. Boutin; David W. Clark; Archie Campbell; Konrad Rawlik; Caroline Hayward; Reka Nagy; Albert Tenesa; David J. Porteous; James F. Wilson; Ian J. Deary; Kathryn L. Evans; Andrew M. McIntosh; Pau Navarro; Chris S. Haley
Source
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Parent-of-origin effects (POE) are observed when there are different effects from alleles inherited from the two parents on phenotypic measures. Here, Zeng et al. study POE on DNA methylation in 5,101 individuals and identify genetic variants that associate with methylation variation via POE and their potential phenotypic consequences.