학술논문
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions
Document Type
article
Author
Malina A. Bakowski; Nathan Beutler; Karen C. Wolff; Melanie G. Kirkpatrick; Emily Chen; Tu-Trinh H. Nguyen; Laura Riva; Namir Shaabani; Mara Parren; James Ricketts; Anil K. Gupta; Kastin Pan; Peiting Kuo; MacKenzie Fuller; Elijah Garcia; John R. Teijaro; Linlin Yang; Debashis Sahoo; Victor Chi; Edward Huang; Natalia Vargas; Amanda J. Roberts; Soumita Das; Pradipta Ghosh; Ashley K. Woods; Sean B. Joseph; Mitchell V. Hull; Peter G. Schultz; Dennis R. Burton; Arnab K. Chatterjee; Case W. McNamara; Thomas F. Rogers
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Here, the authors perform repurposing screens of the ReFRAME drug library in two cell lines and identify inhibitors of SARS-CoV-2 infection. Antiviral activity of prodrug MK-4482 is confirmed in hamsters.