학술논문
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
Document Type
article
Author
Karsten Boldt; Jeroen van Reeuwijk; Qianhao Lu; Konstantinos Koutroumpas; Thanh-Minh T. Nguyen; Yves Texier; Sylvia E. C. van Beersum; Nicola Horn; Jason R. Willer; Dorus A. Mans; Gerard Dougherty; Ideke J. C. Lamers; Karlien L. M. Coene; Heleen H. Arts; Matthew J. Betts; Tina Beyer; Emine Bolat; Christian Johannes Gloeckner; Khatera Haidari; Lisette Hetterschijt; Daniela Iaconis; Dagan Jenkins; Franziska Klose; Barbara Knapp; Brooke Latour; Stef J. F. Letteboer; Carlo L. Marcelis; Dragana Mitic; Manuela Morleo; Machteld M. Oud; Moniek Riemersma; Susan Rix; Paulien A. Terhal; Grischa Toedt; Teunis J. P. van Dam; Erik de Vrieze; Yasmin Wissinger; Ka Man Wu; Gordana Apic; Philip L. Beales; Oliver E. Blacque; Toby J. Gibson; Martijn A. Huynen; Nicholas Katsanis; Hannie Kremer; Heymut Omran; Erwin van Wijk; Uwe Wolfrum; François Kepes; Erica E. Davis; Brunella Franco; Rachel H. Giles; Marius Ueffing; Robert B. Russell; Ronald Roepman; UK10K Rare Diseases Group
Source
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Mutations in proteins that localize to primary cilia cause devastating diseases, yet the primary cilium is a poorly understood organelle. Here the authors use interaction proteomics to identify a network of human ciliary proteins that provides new insights into several biological processes and diseases.