학술논문
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
Document Type
article
Author
David L. Duffy; Gu Zhu; Xin Li; Marianna Sanna; Mark M. Iles; Leonie C. Jacobs; David M. Evans; Seyhan Yazar; Jonathan Beesley; Matthew H. Law; Peter Kraft; Alessia Visconti; John C. Taylor; Fan Liu; Margaret J. Wright; Anjali K. Henders; Lisa Bowdler; Dan Glass; M. Arfan Ikram; André G. Uitterlinden; Pamela A. Madden; Andrew C. Heath; Elliot C. Nelson; Adele C. Green; Stephen Chanock; Jennifer H. Barrett; Matthew A. Brown; Nicholas K. Hayward; Stuart MacGregor; Richard A. Sturm; Alex W. Hewitt; Melanoma GWAS Consortium; Manfred Kayser; David J. Hunter; Julia A. Newton Bishop; Timothy D. Spector; Grant W. Montgomery; David A. Mackey; George Davey Smith; Tamar E. Nijsten; D. Timothy Bishop; Veronique Bataille; Mario Falchi; Jiali Han; Nicholas G. Martin
Source
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Melanocytic nevus count is associated with melanoma risk. In this study, a meta-analysis of 11 nevus GWAS studies identifies novel SNPs in KITLG and 9q32, and bivariate analysis with melanoma GWAS meta-analysis reveals that most nevus genes affect melanoma risk, while melanoma risk loci do not alter the nevus count.