학술논문
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
Document Type
article
Author
Philip J. Law; Sonja I. Berndt; Helen E. Speedy; Nicola J. Camp; Georgina P. Sava; Christine F. Skibola; Amy Holroyd; Vijai Joseph; Nicola J. Sunter; Alexandra Nieters; Silvia Bea; Alain Monnereau; David Martin-Garcia; Lynn R. Goldin; Guillem Clot; Lauren R. Teras; Inés Quintela; Brenda M. Birmann; Sandrine Jayne; Wendy Cozen; Aneela Majid; Karin E. Smedby; Qing Lan; Claire Dearden; Angela R. Brooks-Wilson; Andrew G. Hall; Mark P. Purdue; Tryfonia Mainou-Fowler; Claire M. Vajdic; Graham H. Jackson; Pierluigi Cocco; Helen Marr; Yawei Zhang; Tongzhang Zheng; Graham G. Giles; Charles Lawrence; Timothy G. Call; Mark Liebow; Mads Melbye; Bengt Glimelius; Larry Mansouri; Martha Glenn; Karen Curtin; W Ryan Diver; Brian K. Link; Lucia Conde; Paige M. Bracci; Elizabeth A. Holly; Rebecca D. Jackson; Lesley F. Tinker; Yolanda Benavente; Paolo Boffetta; Paul Brennan; Marc Maynadie; James McKay; Demetrius Albanes; Stephanie Weinstein; Zhaoming Wang; Neil E. Caporaso; Lindsay M. Morton; Richard K. Severson; Elio Riboli; Paolo Vineis; Roel C. H. Vermeulen; Melissa C. Southey; Roger L. Milne; Jacqueline Clavel; Sabine Topka; John J. Spinelli; Peter Kraft; Maria Grazia Ennas; Geoffrey Summerfield; Giovanni M. Ferri; Robert J. Harris; Lucia Miligi; Andrew R. Pettitt; Kari E. North; David J. Allsup; Joseph F. Fraumeni; James R. Bailey; Kenneth Offit; Guy Pratt; Henrik Hjalgrim; Chris Pepper; Stephen J. Chanock; Chris Fegan; Richard Rosenquist; Silvia de Sanjose; Angel Carracedo; Martin J. S. Dyer; Daniel Catovsky; Elias Campo; James R. Cerhan; James M. Allan; Nathanial Rothman; Richard Houlston; Susan Slager
Source
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.