학술논문
Impact of the RNF213 p.R4810K Variant on Endovascular Therapy for Large‐Vessel Occlusion Stroke
Document Type
article
Author
Takeshi Yoshimoto; Kanta Tanaka; Junpei Koge; Satoshi Saito; Hiroshi Yamagami; Yuriko Nakaoku; Soshiro Ogata; Kunihiro Nishimura; Eriko Yamaguchi; Tetsuya Chiba; Daisuke Kawakami; Masayuki Shiozawa; Naruhiko Kamogawa; Tsuyoshi Ohta; Tetsu Satow; Manabu Inoue; Yorito Hattori; Kazuo Washida; Hiroharu Kataoka; Jong‐Won Chung; Oh Young Bang; Kazunori Toyoda; Masatoshi Koga; Hirofumi Maruyama; Masafumi Ihara
Source
Stroke: Vascular and Interventional Neurology, Vol 2, Iss 6 (2022)
Subject
Language
English
ISSN
2694-5746
Abstract
Background We investigated the impact of the ring finger protein 213 p.R4810K variant, a founder variant for moyamoya disease in East Asians, on endovascular therapy outcomes in patients with acute anterior‐circulation large‐vessel occlusion stroke in comparison with noncarriers. Methods Of the consecutive patients with ischemic stroke admitted to our institute from 2011 to 2021, patients who underwent endovascular therapy for acute occlusion of the intracranial internal carotid artery or M1 segment of the middle cerebral artery were included. Outcomes were instant reocclusion, final modified Thrombolysis in Cerebral Infarction reperfusion ≥2b, and early reocclusion. Instant reocclusion was defined as the occurrence of reocclusion during the procedure, and early reocclusion was defined as reocclusion detected on magnetic resonance angiography within 2 weeks after the confirmation of successful reperfusion. Results Of the 277 patients analyzed (128 women; median age, 76 years), 10 patients (3.6%) carried the ring finger protein 213 p.R4810K variant. Variant carriers were younger (P=0.01) and more frequently had intracranial atherosclerotic disease‐related large‐vessel occlusion as a cause of acute large‐vessel occlusion (P