학술논문
Role of the HIV-1 Reservoir to Maintain Viral Suppression in a Simplified Strategy for the Long-Term Management of HIV-1 Infection (The SIMPL’HIV Trial)
Document Type
article
Author
Mattia Branca; Annalisa Marinosci; Delphine Sculier; Gilles Wandeler; Sabine Yerly; Marcel Stoeckle; Enos Bernasconi; Dominique L. Braun; Kathrin Neumann; Pietro Vernazza; Matthias Cavassini; Marta Buzzi; Laurent A. Decosterd; Patrick Schmid; Andreas Limacher; Huldrych F. Günthard; Karin J. Metzner; Alexandra Calmy
Source
Frontiers in Virology, Vol 2 (2022)
Subject
Language
English
ISSN
2673-818X
Abstract
HIV-1 reservoir size and dynamics are promising parameters to ensure the safe prescription of simplified maintenance antiretroviral therapy in chronically HIV-1 infected patients. In the SIMPL’HIV trial, HIV-1 DNA was quantified in peripheral blood mononuclear cells obtained at baseline and week 48 to investigate changes over time and evidence of a predictive relationship to maintain HIV-1 RNA