학술논문
Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model
Document Type
article
Author
Péter J. Hegyi; Alexandra Soós; Emese Tóth; Attila Ébert; Viktória Venglovecz; Katalin Márta; Péter Mátrai; Alexandra Mikó; Judit Bajor; Patrícia Sarlós; Áron Vincze; Adrienn Halász; Ferenc Izbéki; Zoltán Szepes; László Czakó; György Kovács; Mária Papp; Zsolt Dubravcsik; Márta Varga; József Hamvas; Balázs C. Németh; Melania Macarie; Ali Tüzün Ince; Dmitry S. Bordin; Elena A. Dubtsova; Mariya A. Kiryukova; Igor E. Khatkov; Tanya Bideeva; Artautas Mickevicius; Elena Ramírez-Maldonado; Ville Sallinen; Bálint Erőss; Dániel Pécsi; Andrea Szentesi; Andrea Párniczky; László Tiszlavicz; Péter Hegyi
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.