학술논문
Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study.
Document Type
article
Author
Didier K Ekouevi; Eric Balestre; Patrick A Coffie; Daouda Minta; Eugene Messou; Adrien Sawadogo; Albert Minga; Papa Salif Sow; Emmanuel Bissagnene; Serge P Eholie; Geoffrey S Gottlieb; François Dabis; IeDEA West Africa collaboration; Djimon Marcel Zannou; Carin Ahouada; Jocelyn Akakpo; Christelle Ahomadegbé; Jules Bashi; Alice Gougounon-Houéto; Angèle Azon-Kouanou; Fabien Houngbé; Sikiratou Koumakpaï; Florence Alihonou; Marcelline d'Almeida; Irvine Hodonou; Ghislaine Hounhoui; Gracien Sagbo; Leïla Tossa-Bagnan; Herman Adjide; Joseph Drabo; René Bognounou; Arnaud Dienderé; Eliezer Traore; Lassane Zoungrana; Béatrice Zerbo; Adrien Bruno Sawadogo; Jacques Zoungrana; Arsène Héma; Ibrahim Soré; Guillaume Bado; Achille Tapsoba; Diarra Yé; Fla Kouéta; Sylvie Ouedraogo; Rasmata Ouédraogo; William Hiembo; Mady Gansonré; Eugène Messou; Joachim Charles Gnokoro; Mamadou Koné; Guillaume Martial Kouakou; Clarisse Amani Bosse; Kouakou Brou; Achi Isidore Assi; Henri Chenal; Denise Hawerlander; Franck Soppi; Yao Abo; Germain Bomisso; Serge Paul Eholié; Mensah Deborah Noelly Amego; Viviane Andavi; Zelica Diallo; Frédéric Ello; Aristophane Koffi Tanon; Serge Olivier Koule; Koffi Charles Anzan; Calixte Guehi; Edmond Addi Aka; Koffi Ladji Issouf; Jean-Claude Kouakou; Marie-Sylvie N'gbeche; Pety Touré; Divine Avit-Edi; Kouadio Kouakou; Magloire Moh; Valérie Andoblé Yao; Madeleine Amorissani Folquet; Marie-Evelyne Dainguy; Cyrille Kouakou; Véronique Tanoh Méa-Assande; Gladys Oka-Berete; Nathalie Zobo; Patrick Acquah; Marie-Berthe Kokora; Tanoh François Eboua; Marguerite Timité-Konan; Lucrèce Diecket Ahoussou; Julie Kebé Assouan; Mabéa Flora Sami; Clémence Kouadio; Lorna Renner; Bamenla Goka; Jennifer Welbeck; Adziri Sackey; Seth Ntiri Owiafe; Christian Wejse; Zacarias José Da Silva; Joao Paulo; Amabelia Rodrigues; David da Silva; Candida Medina; Ines Oliviera-Souto; Lars Ostergaard; Alex Laursen; Morten Sodemann; Peter Aaby; Anders Fomsgaard; Christian Erikstrup; Jesper Eugen-Olsen; Moussa Y Maïga; Fatoumata Fofana Diakité; Abdoulaye Kalle; Drissa Katile; Hamar Alassane Traore; Tidiani Cissé; Mamadou Dembelé; Mohammed Doumbia; Mahamadou Fomba; Assétou Soukho Kaya; Abdoulaye M Traoré; Hamady Traoré; Amadou Abathina Toure; Fatoumata Dicko; Mariam Sylla; Alima Berthé; Hadizatou Coulibaly Traoré; Anta Koïta; Niaboula Koné; Clémentine N'diaye; Safiatou Touré Coulibaly; Mamadou Traoré; Naïchata Traoré; Man Charurat; Samuel Ajayi; Stephen Dapiap; Otu; Festus Igbinoba; Okwara Benson; Clément Adebamowo; Jesse James; Obaseki; Philip Osakede; John Olasode; Bernard Diop; Noël Magloire Manga; Judicael Malick Tine; Haby Signate Sy; Abou Ba; Aida Diagne; Hélène Dior; Malick Faye; Ramatoulaye Diagne Gueye; Aminata Diack Mbaye; Akessiwe Patassi; Awèrou Kotosso; Benjamin Goilibe Kariyare; Gafarou Gbadamassi; Agbo Komi; Kankoé Edem Mensah-Zukong; Pinuwe Pakpame; Annette Koko Lawson-Evi; Yawo Atakouma; Elom Takassi; Améyo Djeha; Ayoko Ephoévi-Gah; Sherifa El-Hadj Djibril; Elise Arrivé; Patrick Coffie; Didier Ekouevi; Antoine Jaquet; Valériane Leroy; Charlotte Lewden; Annie Sasco; Jean-Claude Azani; Gérard Allou; Franck Bohossou; Sophie Karcher; Jules Mahan Gonsan; Jérôme Le Carrou; Séverin Lenaud; Célestin Nchot; Karen Malateste; Amon Roseamonde Yao; Bertine Siloué; Gwenaelle Clouet; Hugues Djetouan; Alexandra Doring; Adrienne Kouakou; Elodie Rabourdin; Jean Rivenc; Xavier Anglaret; Boubacar Ba; Jean Bosco Essanin; Andrea Ciaranello; Sébastien Datté; Sophie Desmonde; Jean-Serge Elvis Diby; Apollinaire Gninlgninrin Horo; Serge N'zoré Kangah; Denis Malvy; David Meless; Aida Mounkaila-Harouna; Camille Ndondoki; Caroline Shiboski; Rodolphe Thiébaut; Pac-Ci; Abidjan
Source
PLoS ONE, Vol 8, Iss 6, p e66135 (2013)
Subject
Language
English
ISSN
1932-6203
Abstract
HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART) for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA).We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART) and followed-up in clinical centres in the IeDEA-WA network including a total of 13 clinics in five countries: Benin, Burkina-Faso Côte d'Ivoire, Mali, and Senegal, in the West Africa region.Data was merged for 1,754 patients (56% female), including 1,021 HIV-2 infected patients (551 on ART) and 733 dually seropositive for both HIV-1 and HIV 2 (463 on ART). At ART initiation, the median age of HIV-2 patients was 45.3 years, IQR: (38.3-51.7) and 42.4 years, IQR (37.0-47.3) for dually seropositive patients (p = 0.048). Overall, 16.7% of HIV-2 patients on ART had an advanced clinical stage (WHO IV or CDC-C). The median CD4 count at the ART initiation is 166 cells/mm(3), IQR (83-247) among HIV-2 infected patients and 146 cells/mm(3), IQR (55-249) among dually seropositive patients. Overall, in ART-treated patients, the CD4 count increased 126 cells/mm(3) after 24 months on ART for HIV-2 patients and 169 cells/mm(3) for dually seropositive patients. Of 551 HIV-2 patients on ART, 5.8% died and 10.2% were lost to follow-up during the median time on ART of 2.4 years, IQR (0.7-4.3).This large multi-country study of HIV-2 and HIV-1/HIV-2 dual infection in West Africa suggests that routine clinical care is less than optimal and that management and treatment of HIV-2 could be further informed by ongoing studies and randomized clinical trials in this population.