학술논문
Identification of new genetic risk variants for type 2 diabetes.
Document Type
article
Author
Xiao Ou Shu; Jirong Long; Qiuyin Cai; Lu Qi; Yong-Bing Xiang; Yoon Shin Cho; E Shyong Tai; Xiangyang Li; Xu Lin; Wong-Ho Chow; Min Jin Go; Mark Seielstad; Wei Bao; Huaixing Li; Marilyn C Cornelis; Kai Yu; Wanqing Wen; Jiajun Shi; Bok-Ghee Han; Xue Ling Sim; Liegang Liu; Qibin Qi; Hyung-Lae Kim; Daniel P K Ng; Jong-Young Lee; Young Jin Kim; Chun Li; Yu-Tang Gao; Wei Zheng; Frank B Hu
Source
PLoS Genetics, Vol 6, Iss 9, p e1001127 (2010)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, suggesting that the majority of inter-person genetic variation in this disease remains to be determined. We conducted a multistage, genome-wide association study (GWAS) within the Asian Consortium of Diabetes to search for T2D susceptibility markers. From 590,887 SNPs genotyped in 1,019 T2D cases and 1,710 controls selected from Chinese women in Shanghai, we selected the top 2,100 SNPs that were not in linkage disequilibrium (r(2)