학술논문
March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity
Document Type
article
Author
Thiago J. Borges; Naoka Murakami; Felipe D. Machado; Ayesha Murshid; Benjamin J. Lang; Rafael L. Lopes; Laura M. Bellan; Mayuko Uehara; Krist H. Antunes; Maria José Pérez-Saéz; Gabriel Birrane; Priscila Vianna; João Ismael B. Gonçalves; Rafael F. Zanin; Jamil Azzi; Reza Abdi; Satoshi Ishido; Jeoung-Sook Shin; Ana Paula D. Souza; Stuart K. Calderwood; Leonardo V. Riella; Cristina Bonorino
Source
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Donor-derived dendritic cells (do-DC) in the graft can contribute to the induction of alloimmunity and tissue rejection, but how do-DC can be targeted for improving graft survival is unclear. Here the authors show that reducing MHC-II expression on do-DCs by DnaK pre-treatment can decrease the priming of alloimmunity and prolong graft survival in mouse models.