부산대학교 도서관

Abstract Background Premeditated induction chemotherapy followed by surgical resection is accepted as safe and effective. Studies on salvage surgery in patients with incompletely cured lung cancer are lacking. This study aimed to demonstrate the safety and efficacy of salvage surgery. Methods We conducted a retrospective multi‐institutional cohort study on patients who underwent salvage surgery for advanced (stage III and IV) non‐small cell lung cancer (NSCLC) between January 2005 and December 2016 at the 14 hospitals of the Chubu Lung Cancer Surgery Study Group. A total of 37 patients were assigned to the salvage surgery group; a lobectomy with mediastinal lymph node dissection was performed. The survival benefit was assessed using the Kaplan–Meier method and the Cox proportional hazard model. Results Although postoperative complications were observed in 11 patients (29.7%), surgery‐related death occurred in only one patient (mortality rate: 2.7%) resulting from respiratory failure caused by interstitial pneumonia exacerbation. Postoperative recurrence was observed in 22 patients (61.1%), the incidence of brain metastasis being high (nine patients: 40.9%). The five‐year survival rate from the first day of treatment was 60%. The survival of the postoperative pathological stage (s'‐stage) I group was significantly better (five‐year survival rate: 80.9%) than that of the other groups (p