학술논문

Contrast‐Enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract
Document Type
article
Source
Advanced Science, Vol 10, Iss 23, Pp n/a-n/a (2023)
Subject
indocyanine green
intestine
multispectral optoacoustic tomography
optoacoustics
photoacoustics
Science
Language
English
ISSN
2198-3844
Abstract
Abstract Real‐time imaging and functional assessment of the intestinal tract and its transit pose a significant challenge to conventional clinical diagnostic methods. Multispectral optoacoustic tomography (MSOT), a molecular‐sensitive imaging technology, offers the potential to visualize endogenous and exogenous chromophores in deep tissue. Herein, a novel approach using the orally administered clinical‐approved fluorescent dye indocyanine green (ICG) for bedside, non‐ionizing evaluation of gastrointestinal passage is presented. The authors are able to show the detectability and stability of ICG in phantom experiments. Furthermore, ten healthy subjects underwent MSOT imaging at multiple time points over eight hours after ingestion of a standardized meal with and without ICG. ICG signals can be visualized and quantified in different intestinal segments, while its excretion is confirmed by fluorescent imaging of stool samples. These findings indicate that contrast‐enhanced MSOT (CE‐MSOT) provides a translatable real‐time imaging approach for functional assessment of the gastrointestinal tract.