학술논문
Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis
Document Type
article
Author
Richard H. Kimura; Ling Wang; Bin Shen; Li Huo; Willemieke Tummers; Fabian V. Filipp; Haiwei Henry Guo; Thomas Haywood; Lotfi Abou-Elkacem; Lucia Baratto; Frezghi Habte; Rammohan Devulapally; Timothy H. Witney; Yan Cheng; Suhas Tikole; Subhendu Chakraborti; Jay Nix; Christopher A. Bonagura; Negin Hatami; Joshua J. Mooney; Tushar Desai; Scott Turner; Richard S. Gaster; Andrea Otte; Brendan C. Visser; George A. Poultsides; Jeffrey Norton; Walter Park; Mark Stolowitz; Kenneth Lau; Eric Yang; Arutselvan Natarajan; Ohad Ilovich; Shyam Srinivas; Ananth Srinivasan; Ramasamy Paulmurugan; Juergen Willmann; Frederick T. Chin; Zhen Cheng; Andrei Iagaru; Fang Li; Sanjiv S. Gambhir
Source
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Knottin is a cystine knot peptide. Here, the authors develop a knottin-based tracer for positron emission tomography and demonstrate its ability to detect cancer and idiopathic pulmonary fibrosis through selective binding to integrin αvβ6.