학술논문
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer
Document Type
article
Author
Emily Golden; Rabab Rashwan; Eleanor A. Woodward; Agustin Sgro; Edina Wang; Anabel Sorolla; Charlene Waryah; Wan Jun Tie; Elisabet Cuyàs; Magdalena Ratajska; Iwona Kardaś; Piotr Kozlowski; Elizabeth K. M. Johnstone; Heng B. See; Ciara Duffy; Jeremy Parry; Kim A. Lagerborg; Piotr Czapiewski; Javier A. Menendez; Adam Gorczyński; Bartosz Wasag; Kevin D. G. Pfleger; Christina Curtis; Bum-Kyu Lee; Jonghwan Kim; Joseph Cursons; Nathan J. Pavlos; Wojciech Biernat; Mohit Jain; Andrew J. Woo; Andrew Redfern; Pilar Blancafort
Source
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic reprogramming.