학술논문
Evaluation of nationwide supplementary immunization in Lao People's Democratic Republic: Population-based seroprevalence survey of anti-measles and anti-rubella IgG in children and adults, mathematical modelling and a stability testing of the vaccine.
Document Type
article
Author
Masahiko Hachiya; Shinsuke Miyano; Yoshio Mori; Emilia Vynnycky; Phath Keungsaneth; Phengta Vongphrachanh; Anonh Xeuatvongsa; Thongchanh Sisouk; Vilasak Som-Oulay; Bouaphan Khamphaphongphane; Bounthanom Sengkeopaseuth; Chansay Pathammavong; Kongxay Phounphenghak; Tomomi Kitamura; Makoto Takeda; Katsuhiro Komase
Source
PLoS ONE, Vol 13, Iss 3, p e0194931 (2018)
Subject
Language
English
ISSN
1932-6203
Abstract
Measles outbreaks have occurred in some countries despite supplementary immunization activities (SIA) using measles-containing vaccine with high vaccination coverage. We conducted a cross-sectional seroprevalence survey to estimate population immunity in Lao People's Democratic Republic where repeated mass immunization has failed to eliminate measles.In this nationwide multistage cluster sampling survey conducted in 2014 based on probability proportionate to size sampling, blood samples were collected from 2,135 children and adults living in 52 randomly selected villages. Anti-measles and anti-rubella IgG were measured, and IgG prevalence was calculated. We applied mathematical modelling to estimate the number of cases of congenital rubella syndrome (CRS) in 2013 that were averted by the 2011 SIA. A stability testing was applied to the MR vaccine at 4°C, 25°C, and 35°C to examine stability differences between measles and rubella vaccine components. Measles IgG prevalence was significantly lower in the target age groups (5-21 years) of the 2011 SIA using a combination vaccine for measles and rubella vaccine (MR vaccine) than in young adults (22-39 years) (86.8% [95% CI: 83.0-90.6] vs. 99.0% [98.3-99.8]; p