학술논문
Severity of Omicron (B.1.1.529) and Delta (B.1.617.2) SARS-CoV-2 infection among hospitalised adults: A prospective cohort study in Bristol, United KingdomResearch in context
Document Type
article
Author
Catherine Hyams; Robert Challen; Robin Marlow; Jennifer Nguyen; Elizabeth Begier; Jo Southern; Jade King; Anna Morley; Jane Kinney; Madeleine Clout; Jennifer Oliver; Sharon Gray; Gillian Ellsbury; Nick Maskell; Luis Jodar; Bradford Gessner; John McLaughlin; Leon Danon; Adam Finn; Amelia Langdon; Anabella Turner; Anya Mattocks; Bethany Osborne; Charli Grimes; Claire Mitchell; David Adegbite; Emma Bridgeman; Emma Scott; Fiona Perkins; Francesca Bayley; Gabriella Ruffino; Gabriella Valentine; Grace Tilzey; James Campling; Johanna Kellett Wright; Julia Brzezinska; Julie Cloake; Katarina Milutinovic; Kate Helliker; Katie Maughan; Kazminder Fox; Konstantina Minou; Lana Ward; Leah Fleming; Leigh Morrison; Lily Smart; Louise Wright; Lucy Grimwood; Maddalena Bellavia; Marianne Vasquez; Maria Garcia Gonzalez; Milo Jeenes-Flanagan; Natalie Chang; Niall Grace; Nicola Manning; Oliver Griffiths; Pip Croxford; Peter Sequenza; Rajeka Lazarus; Rhian Walters; Robyn Heath; Rupert Antico; Sandi Nammuni Arachchge; Seevakumar Suppiah; Taslima Mona; Tawassal Riaz; Vicki Mackay; Zandile Maseko; Zoe Taylor; Zsolt Friedrich; Zsuzsa Szasz-Benczur
Source
The Lancet Regional Health. Europe, Vol 25, Iss , Pp 100556- (2023)
Subject
Language
English
ISSN
2666-7762
Abstract
Summary: Background: There is an urgent public health need to evaluate disease severity in adults hospitalised with Delta and Omicron SARS-CoV-2 variant infections. However, limited data exist assessing severity of disease in adults hospitalised with Omicron SARS-CoV-2 infections, and to what extent patient-factors, including vaccination, age, frailty and pre-existing disease, affect variant-dependent disease severity. Methods: A prospective cohort study of adults (≥18 years of age) hospitalised with acute lower respiratory tract disease at acute care hospitals in Bristol, UK conducted over 10-months. Delta or Omicron SARS-CoV-2 infection was defined by positive SARS-CoV-2 PCR and variant identification or inferred by dominant circulating variant. We constructed adjusted regression analyses to assess disease severity using three different measures: FiO2 >28% (fraction inspired oxygen), World Health Organization (WHO) outcome score >5 (assessing need for ventilatory support), and hospital length of stay (LOS) >3 days following admission for Omicron or Delta infection. Findings: Independent of other variables, including vaccination, Omicron variant infection in hospitalised adults was associated with lower severity than Delta. Risk reductions were 58%, 67%, and 16% for supplementary oxygen with >28% FiO2 [Relative Risk (RR) = 0.42 (95%CI: 0.34–0.52), P 5 [RR = 0.33 (95%CI: 0.21–0.50), P 3 days [RR = 0.84 (95%CI: 0.76–0.92), P