학술논문
Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of AML. Here, the authors report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and provide evidence of a direct link between the association of NUP98-PHD finger chimeras with H3K4me3-rich regions and leukemic transformation.