학술논문
Impact of Valproate and Levetiracetam Exposure on GAERS Behavior During Pregnancy
Document Type
article
Author
Source
Archives of Epilepsy, Vol 29, Iss 3, Pp 69-74 (2023)
Subject
Language
English
ISSN
2792-0550
Abstract
Objective:Valproate (VPA) and levetiracetam (LEV) are frequently prescribed for the management of idiopathic generalized seizures; however, their well-documented teratogenic effects raise concerns when administered to pregnant epileptic patients. This study aimed to assess the impact of VPA and LEV exposure during pregnancy on Genetic Absence Epilepsy Rats from Strasbourg (GAERS).Methods:Female GAERS rats were categorized into three groups: saline-treated (n=6), VPA-treated (200 mg/kg, n=4), and LEV-treated (50 mg/kg, n=6). Intraperitoneal injections were initiated from mating start and continued until partition. Locomotor activity and anxiety-like behavior were evaluated using open-field and hole-board tests for the VPA-treated and VPA- and LEV-treated groups; respectively. These tests were conducted both before and during pregnancy.Results:Across all groups, open-field testing demonstrated a tendency toward reduced locomotor activity parameters compared with pre-pregnancy, with VPA treatment showing significance (p