학술논문
Clinical outcomes and anticoagulation therapy in elderly non‐valvular atrial fibrillation and heart failure patients
Document Type
article
Author
Shota Ikeda; Ken‐ichi Hiasa; Hiroshi Inoue; Takeshi Yamashita; Masaharu Akao; Hirotsugu Atarashi; Yukihiro Koretsune; Ken Okumura; Wataru Shimizu; Shinya Suzuki; Takanori Ikeda; Kazunori Toyoda; Atsushi Hirayama; Masahiro Yasaka; Takenori Yamaguchi; Satoshi Teramukai; Tetsuya Kimura; Yoshiyuki Morishima; Atsushi Takita; Hiroyuki Tsutsui
Source
ESC Heart Failure, Vol 11, Iss 2, Pp 902-913 (2024)
Subject
Language
English
ISSN
2055-5822
Abstract
Abstract Aims Atrial fibrillation (AF) and heart failure (HF) often coexist. Older age is strongly associated with stroke, HF, and mortality. The association between coexistence of HF and a risk of clinical outcomes and the effectiveness of anticoagulation therapy including direct oral anticoagulants (DOACs) in elderly patients with AF and HF have not been investigated. We aimed to evaluate 2 years of outcomes and to elucidate the efficacy of DOACs or warfarin in elderly AF patients in the All Nippon AF In the Elderly (ANAFIE) Registry with and without a history of HF. Methods and results The ANAFIE Registry is a multicentre, prospective observational study following elderly non‐valvular AF patients aged ≥75 years for 2 years. Hazard ratios (HRs) were calculated based on the presence or absence of an HF diagnosis and DOAC or warfarin use at enrolment. Among 32 275 eligible patients, 12 116 (37.5%) had been diagnosed with HF. Patients with HF had significantly higher rates of HF hospitalization or cardiovascular death (HR 1.94, P