학술논문
Low-Density Lipoprotein Cholesterol and Mortality in Patients With Intracerebral Hemorrhage in Taiwan
Document Type
article
Author
Chi-Pang Wen; Yi-Che Lee; Yuan-Ting Sun; Chih-Yuan Huang; Chon-Haw Tsai; Po-Lin Chen; Wei-Lun Chang; Po-Yen Yeh; Cheng-Yu Wei; Ming-Jun Tsai; Yu Sun; Chih-Hao Lin; Jiunn-Tay Lee; Ta-Chang Lai; Li-Ming Lien; Mei-Chen Lin; Cheng-Li Lin; June-Han Lee; Hao-Kuang Wang; Chung Y. Hsu; Taiwan Stroke Registry Investigators; Chung-Hsiang Liu; Wei-Shih Huang; Chung-Ta Lu; Tzung-Chang Tsai; Chun-Hung Tseng; Kang-Hsu Lin; Woei-Cherng Shyn; Yu-Wan Yang; Yen-Liang Liu; Der-Yang Cho; Chun-Chung Chen; Shih-Pin Hsu; Han-Jung Chen; Cheng-Sen Chang; Hung-Chang Kuo; Lian-Hui Lee; Huan-Wen Tsui; Jung-Chi Tsou; Yan-Tang Wang; Yi-Cheng Tai; Kun-Chang Tsai; Yen-Wen Chen; Kang Lu; Po-Chao Liliang; Yu-Tun Tsai; Cheng-Loong Liang; Kuo-Wei Wang; Jui-Sheng Chen; Po-Yuan Chen; Cien-Leong Chye; Wei-Jie Tzeng; Pei-Hua Wu; Chih-Hung Chen; Han-Chieh Hsieh; Hui-Chen Su; Yu-Shan Lee; Hsin-Yi Chi; Chou-Hsiung Pan; Po-Chi Chan; Min-Hsien Hsu; Ya-Ying Wu; Zhi-Zang Huang; Hai-Ming Shoung; Yi-Chen Lo; Fu-Hwa Wang; Chien-Chung Chen; Yu-Tai Tsai; Ko-Yi Wang; Tzu-Hsuan Huang; Chao-Nan Yang; Chao-Hsien Hung; Ian Shih; Hsin-Yi Kao; Chien-Jung Lu; Cheng-Huai Lin; Chieh-Cheng Huang; Chang-Hsiu Liu; Hoi-Fong Chan; Ping-Kun Chen; Pai-Yi Chiu; Jiann-Chyun Lin; Yaw-Don Hsu; Jong-Chyou Denq; Giia-Sheun Peng; Chang-Hung Hsu; Chun-Chieh Lin; Che-Hung Yen; Chun-An Cheng; Yueh-Feng Sung; Yuan-Liang Chen; Ming-Tung Lien; Chung-Hsing Chou; Chia-Chen Liu; Fu-Chi Yang; Yi-Chung Wu; An-Chen Tso; Yu-Hua Lai; Chun-I Chiang; Chia-Kuang Tsai; Meng-Ta Liu; Ying-Che Lin; Yu-Chuan Hsu; Jiu-Haw Yin; Chung-JenWang; Kai-ChenWang; Li-Mei Chen; Hou-Chang Chiu; Wei-Hung Chen; Chyi-Huey Bai; Chi-Ieong Lau; Hsu-Ling Yeh; Anna Chang; Jiann-Shing Jeng; Sung-Chun Tang; Li-Kai Tsai; Shin-Joe Yeh; Ching-Huang Lin; Cheng-Chang Yen; Ruey-Tay Lin; Chun-Hung Chen; Gim-Thean Khor; A-Ching Chao; Hsiu-Fen Lin; Poyin Huang; Huey-Juan Lin; Der-Shin Ke; Chia-Yu Chang; Poh-Shiow Yeh; Kao-Chang Lin; Tain-Junn Cheng; Chih-Ho Chou; Chun-Ming Yang; Hsiu-Chu Shen; An-Chih Chen; Shih-Jei Tsai; Tsong-Ming Lu; Sheng-Ling Kung; Mei-Ju Lee; Hsi-Hsien Chou; Siu-Pak Lee; Ming-Hui Sun; Li-Ying Ke; Sheng-Feng Sung; Cheung-Ter Ong; Chi-Shun Wu; Yu-Hsiang Su; Ling-Chien Hung; Tsuey-Ru Chiang; Mei-Ching Lee; Pai-Hao Huang; Sian-King Lie; Pin-Wen Liao; Jen-Tse Chen; Mu-Chien Sun; Tien-Pao Lai; Wei-Liang Chen; Yen-Chun Chen; Ta-Cheng Chen; Wen-Fu Wang; Kwo-Whei Lee; Chen-Shu Chang; Chien-Hsu Lai; Siao-Ya Shih; Chieh-Sen Chuang; Yen-Yu Chen; Chien-Min Chen; Shinn-Kuang Lin; Yu-Chin Su; Cheng-Lun Hsiao; Fu-Yi Yang; Chih-Yang Liu; Han-Lin Chiang; Ser-Chen Fu; Chun-Yuan Chang; I-sheng Lin; Chung-Hsien Chien; Yang-Chuang Chang; Yu-Jen Hsiao; Chen-Wen Fang; Yu-Wei Chen; Kuo-Ying Lee; Yun-Yu Lin; Chen-Hua Li; Hui-Fen Tsai; Chuan-Fa Hsieh; Chih-Dong Yang; Shiumn-Jen Liaw; How-Chin Liao; Shoou-Jeng Yeh; Liang-Po Hsieh; Yong-Hui Lee; Chung-Wen Chen; Chih-Shan Hsu; Ye-Jian-Jhih; Hao-Yu Zhuang; Yan-Hong Pan; Shin-An Shih; Chin-I Chen; Jia-Ying Sung; Hsing-Yu Weng; Hao-Wen Teng; Jing-Er Lee; Chih-Shan Huang; Shu-Ping Chao; Rey-Yue Yuan; Jau-Jiuan Sheu; Jia-Ming Yu; Chun-Sum Ho; Ting-Chun Lin; Shih-Chieh Yu; Jiunn-Rong Chen; Song-Yen Tsai; Hung-Pin Tseng; Chin-Hsiung Liu; Chun-Liang Lin; Hung-Chih Lin; Pi-Tzu Chen; Chaur-Jong Hu; Nai-Fang Chi; Lung Chan; Chang-Ming Chern; Chun-Jen Lin; Shuu-Jiun Wang; Li-Chi Hsu; Wen-Jang Wong; I-Hui Lee; Der-Jen Yen; Ching-Piao Tsai; Shang-Yeong Kwan; Bing-Wen Soong; Shih-Pin Chen; Kwong-Kum Liao; Kung-Ping Lin; Chien Chen; Din-E Shan; Jong-Ling Fuh; Pei-Ning Wang; Yi-Chung Lee; Yu-Hsiang Yu; Hui-Chi Huang; Jui-Yao Tsai; Ming-Hsiu Wu; Shi-Cheng Chen; Chiung-Yao Wang; Ming-Chin Hsu; Tsang-Shan Chen; Ping-Keung Yip; Vinchi Wang; Kaw-ChenWang; Chung-Fen Tsai; Chao-Ching Chen; Chih-Hao Chen; Yi-Chien Liu; Shao-Yuan Chen; Zi-Hao Zhao; Zhi-Peng Wei; Shey-Lin Wu; Ching-Kuan Liu; Ryh-Huei Lin; Ching-Hua Chu; Sui-Hing Yan; Yi-Chun Lin; Pei-Yun Chen; Sheng-Huang Hsiao; Bak-Sau Yip; Pei-Chun Tsai; Ping-Chen Chou; Tsam-Ming Kuo; Yi-Chen Lee; Yi-Pin Chiu; Yi-Sheng Liao
Source
Frontiers in Neurology, Vol 12 (2022)
Subject
Language
English
ISSN
1664-2295
Abstract
Objective: Lower serum low-density lipoprotein cholesterol (LDL-C) levels are associated with increased intracerebral hemorrhage (ICH) risk. However, reverse causality and residual confounding has not attracted public attention. Therefore, we assessed whether people with LDL-C have increased risk of mortality adjusting for potential confounders using two large Taiwan cohorts.Methods: The Mei-Jhao (MJ) cohort has 414,372 adults participating in a medical screening program with 378 ICH deaths within 15 years of follow-up (1994–2008). Cox proportional hazards regressions estimated hazard death ratios according to LDL-C levels. We identified 4,606 ICH patients from the Taiwan Stroke Registry (TSR) and analyzed the impact of LDL-C on 3-month mortality.Results: Low cholesterol (LDL-C