학술논문
Parvimonas micra can translocate from the subgingival sulcus of the human oral cavity to colorectal adenocarcinoma
Document Type
article
Author
Kelly Conde‐Pérez; Elena Buetas; Pablo Aja‐Macaya; Elsa Martin‐De Arribas; Iago Iglesias‐Corrás; Noelia Trigo‐Tasende; Mohammed Nasser‐Ali; Lara S. Estévez; Soraya Rumbo‐Feal; Begoña Otero‐Alén; Jose F. Noguera; Ángel Concha; Simón Pardiñas‐López; Miguel Carda‐Diéguez; Igor Gómez‐Randulfe; Nieves Martínez‐Lago; Susana Ladra; Luis A. Aparicio; Germán Bou; Alex Mira; Juan A. Vallejo; Margarita Poza
Source
Molecular Oncology, Vol 18, Iss 5, Pp 1143-1173 (2024)
Subject
Language
English
ISSN
1878-0261
1574-7891
1574-7891
Abstract
Oral and intestinal samples from a cohort of 93 colorectal cancer (CRC) patients and 30 healthy controls (non‐CRC) were collected for microbiome analysis. Saliva (28 non‐CRC and 94 CRC), feces (30 non‐CRC and 97 CRC), subgingival fluid (20 CRC), and tumor tissue samples (20 CRC) were used for 16S metabarcoding and/or RNA sequencing (RNAseq) approaches. A differential analysis of the abundance, performed with the ANCOM‐BC package, adjusting the P‐values by the Holm‐Bonferroni method, revealed that Parvimonas was significantly over‐represented in feces from CRC patients (P‐value