학술논문
Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malariaResearch in context
Document Type
article
Author
Mavuto Mukaka; Marie A. Onyamboko; Peter Olupot-Olupot; Pimnara Peerawaranun; Kanokon Suwannasin; Watcharee Pagornrat; Jindarat Kouhathong; Wanassanan Madmanee; Winifred Were; Cate Namayanja; Peter Onyas; Harriet Titin; Joy Baseke; Rita Muhindo; Daddy K. Kayembe; Pauline O. Ndjowo; Benjamin B. Basara; Georgette S. Bongo; Charles B. Okalebo; Grace Abongo; Sophie Uyoga; Thomas N. Williams; Chiraporn Taya; Mehul Dhorda; Arjen M. Dondorp; Naomi Waithira; Mallika Imwong; Kathryn Maitland; Caterina Fanello; Nicholas P.J. Day; Joel Tarning; Nicholas J. White; Walter R.J. Taylor
Source
EBioMedicine, Vol 96, Iss , Pp 104805- (2023)
Subject
Language
English
ISSN
2352-3964
Abstract
Summary: Background: There are no pharmacokinetic data of single low dose primaquine (SLDPQ) as transmission blocking in African children with acute Plasmodium falciparum and glucose-6-phosphate dehydrogenase deficiency (G6PDd). Methods: Primaquine pharmacokinetics of age-dosed SLDPQ (shown previously to be gametocytocidal with similar tolerability as placebo) were characterised in falciparum-infected Ugandan and Congolese children aged 6 months to 11 years, treated on admission with standard 3-day dihydroartemisinin-piperaquine or artemether-lumefantrine plus SLDPQ: 6 m–