학술논문
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
STING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 interferon production does not affect susceptibility to HSV-1 infection.