학술논문
Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo
Document Type
article
Author
Konxhe Kulaj; Alexandra Harger; Michaela Bauer; Özüm S. Caliskan; Tilak Kumar Gupta; Dapi Menglin Chiang; Edward Milbank; Josefine Reber; Angelos Karlas; Petra Kotzbeck; David N. Sailer; Francesco Volta; Dominik Lutter; Sneha Prakash; Juliane Merl-Pham; Vasilis Ntziachristos; Hans Hauner; Michael W. Pfaffl; Matthias H. Tschöp; Timo D. Müller; Stefanie M. Hauck; Benjamin D. Engel; Jantje M. Gerdes; Paul T. Pfluger; Natalie Krahmer; Kerstin Stemmer
Source
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Extracellular vesicles (EVs) convey inter-organ communication in health and disease. Here, the authors report that adipocyte-derived EVs isolated from insulin-resistant obese but not lean male mice stimulate insulin secretion via the targeted transfer of insulinotropic proteins from adipose tissue to β-cells.