학술논문
Sex-differential cognitive performance on MCCB of youth with BD-II depression
Document Type
article
Author
Source
BMC Psychiatry, Vol 24, Iss 1, Pp 1-10 (2024)
Subject
Language
English
ISSN
1471-244X
Abstract
Abstract Background Recent evidences have shown sex-differential cognitive deficits in bipolar disorder (BD) and differences in cognitions across BD subtypes. However, the sex-specific effect on cognitive impairment in BD subtype II (BD-II) remains obscure. The aim of the current study was to examine whether cognitive deficits differ by gender in youth with BD-II depression. Method This cross-sectional study recruited 125 unmedicated youths with BD-II depression and 140 age-, sex-, and education-matched healthy controls (HCs). The Chinese version of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) was used to assess cognitive functions. Mood state was assessed using the 24-item Hamilton Depression Rating Scale (24-HDRS) and the Young Mania Rating Scale (YMRS). Multivariate analysis of covariance (MANCOVA) was conducted. Result Compared with HCs, patients with BD-II depression had lower scores on MCCB composite and its seven cognitive domains (all p