학술논문
Siderophore production as a biomarker for Klebsiella pneumoniae strains that cause sepsis: A pilot study
Document Type
article
Author
Source
Journal of the Formosan Medical Association, Vol 121, Iss 4, Pp 848-855 (2022)
Subject
Language
English
ISSN
0929-6646
Abstract
Background/purpose: Klebsiella pneumoniae bacteremia-induced sepsis is a clinically important condition with a high mortality rate and various known virulence factors. However, studies on the association of these virulence factors with the occurrence of K. pneumoniae bacteremia-induced sepsis are scarce. We aimed to investigate clinical variables and virulence factors in patients with K. pneumoniae bacteremia-induced sepsis. Methods: We retrospectively reviewed the medical records of 76 patients with K. pneumoniae bacteremia between January 2012 and July 2017. Patients were divided into sepsis (n = 25) and non-sepsis (n = 51) groups. Patient background characteristics, antimicrobial regimens, and prognosis were evaluated. We assessed the distribution of virulence factors related to K. pneumoniae, such as mucoviscosity, capsular polysaccharide, and siderophores. Siderophore production levels were determined by measuring the orange halo zone on chrome azurol S agar plate assay. Results: There were no intergroup differences in male-to-female ratio and age. Multivariable analysis revealed that siderophore production level (p