학술논문
The prospective multiple-centre randomized controlled clinical study of high-dose amoxicillin-proton pump inhibitor dual therapy for H. pylori infection in Sichuan areas
Document Type
article
Author
Cheng Shen; Changping Li; Muhan Lv; Xiaosong Dai; Caiping Gao; Liangping Li; Qin Zhang; Wen Pan; Chao Liu; Sijing Han; Yang Zhang; Shunbin Ding; Hong Deng; Yong Yao; Jianyu Xu; Mingyong Wei; Haiyan Shi; Peijie Yuan; Xiaoyan Yang; Yi Jian; Jing Shan; Yan Liu; Zonghua Chen; Xuejie Deng; Fei Liu; Lijuan Deng; Xianfei Zhong; Hong Li; Shaoya He; Li Chen; Gang Liu; Hairong Xu; Yuquan Zhong; Hua Shi; Jiangang Ren; The Multi-Center Clinical Research Collaboration Group of Sichuan Provincial H. pylori Scientific Group, Sichuan Provincial Medical Association
Source
Annals of Medicine, Vol 54, Iss 1, Pp 426-435 (2022)
Subject
Language
English
ISSN
0785-3890
1365-2060
07853890
1365-2060
07853890
Abstract
Objectives To evaluate the safety and efficacy of high-dose amoxicillin-proton pump inhibitor dual therapy, and to provide a new eradication regimen as a first-line option for patients with H. pylori infection. Methods A total of 971 H. pylori positive patients who received initial treatment were recruited from March to August 2020, and randomly divided into treatment group and control group. The treatment group received of 20 mg esomeprazole four times daily and 750 mg amoxicillin four times daily for 14 days. Control group received of 220 mg bismuth potassium citrate twice daily, 20 mg esomeprazole twice daily, 1000 mg amoxicillin twice daily and 250 mg clarithromycin capsule twice daily for 14 days. Four weeks after the end of treatment, the urea breath test was reviewed to detect whether H. pylori was eradicated. Results There were no statistical differences in age, gender, the total clinical symptom scores before and after initial treatment, the compliance, and the degree of remission of symptoms before and after initial treatment between the two groups. The eradication rates of H. pylori between dual therapy and quadruple therapy were 88.31% and 85.26% (p=.158) by intention-to-treat (ITT) analysis, 88.66% and 85.44% (p=.186) by modified intention-to-treat (mITT) analysis, and 91.63% and 90.60% (p=.116) by PP analysis, respectively. Adverse events in dual therapy group were significantly lower than quadruple therapy group (13.3% vs. 28.2% (p