학술논문
SARS-CoV-2 seroprevalence among the general population and healthcare workers in India, December 2020–January 2021
Document Type
article
Author
Manoj V. Murhekar; Tarun Bhatnagar; Jeromie Wesley Vivian Thangaraj; V. Saravanakumar; Muthusamy Santhosh Kumar; Sriram Selvaraju; Kiran Rade; C.P. Girish Kumar; R. Sabarinathan; Alka Turuk; Smita Asthana; Rakesh Balachandar; Sampada Dipak Bangar; Avi Kumar Bansal; Vishal Chopra; Dasarathi Das; Alok Kumar Deb; Kangjam Rekha Devi; Vikas Dhikav; Gaurav Raj Dwivedi; S. Muhammad Salim Khan; M. Sunil Kumar; Avula Laxmaiah; Major Madhukar; Amarendra Mahapatra; Chethana Rangaraju; Jyotirmayee Turuk; Rajiv Yadav; Rushikesh Andhalkar; K. Arunraj; Dinesh Kumar Bharadwaj; Pravin Bharti; Debdutta Bhattacharya; Jyothi Bhat; Ashrafjit S. Chahal; Debjit Chakraborty; Anshuman Chaudhury; Hirawati Deval; Sarang Dhatrak; Rakesh Dayal; D. Elantamilan; Prathiksha Giridharan; Inaamul Haq; Ramesh Kumar Hudda; Babu Jagjeevan; Arshad Kalliath; Srikanta Kanungo; Nivethitha N. Krishnan; Jaya Singh Kshatri; Alok Kumar; Niraj Kumar; V.G. Vinoth Kumar; G.G.J. Naga Lakshmi; Ganesh Mehta; Nandan Kumar Mishra; Anindya Mitra; K. Nagbhushanam; Arlappa Nimmathota; A.R. Nirmala; Ashok Kumar Pandey; Ganta Venkata Prasad; Mariya Amin Qurieshi; Sirasanambatti Devarajulu Reddy; Aby Robinson; Seema Sahay; Rochak Saxena; Krithikaa Sekar; Vijay Kumar Shukla; Hari Bhan Singh; Prashant Kumar Singh; Pushpendra Singh; Rajeev Singh; Nivetha Srinivasan; Dantuluri Sheethal Varma; Ankit Viramgami; Vimith Cheruvathoor Wilson; Surabhi Yadav; Suresh Yadav; Kamran Zaman; Amit Chakrabarti; Aparup Das; R.S. Dhaliwal; Shanta Dutta; Rajni Kant; A.M. Khan; Kanwar Narain; Somashekar Narasimhaiah; Chandrasekaran Padmapriyadarshini; Krishna Pandey; Sanghamitra Pati; Shripad Patil; Hemalatha Rajkumar; Tekumalla Ramarao; Y.K. Sharma; Shalini Singh; Samiran Panda; D.C.S. Reddy; Balram Bhargava; Tanu Anand; Giridhara R. Babu; Himanshu Chauhan; Tanzin Dikid; Raman R. Gangakhedkar; Shashi Kant; Sanket Kulkarni; J.P. Muliyil; Ravindra Mohan Pandey; Swarup Sarkar; Naman Shah; Aakash Shrivastava; Sujeet K. Singh; Sanjay Zodpe; Anusha Hindupur; P.R. Asish; M. Chellakumar; D. Chokkalingam; Sauvik Dasgupta; M.M.E. Gowtham; Annamma Jose; K. Kalaiyarasi; N.N. Karthik; T. Karunakaran; G. Kiruthika; H. Dinesh Kumar; S. Sarath Kumar; M.P. Sarath Kumar; E. Michaelraj; Josephine Pradhan; E.B. Arun Prasath; D. Gladys Angelin Rachel; Sudha Rani; Amanda Rozario; R. Sivakumar; P. Gnana Soundari; K. Sujeetha; Arya Vinod
Source
International Journal of Infectious Diseases, Vol 108, Iss , Pp 145-155 (2021)
Subject
Language
English
ISSN
1201-9712
Abstract
Background: Earlier serosurveys in India revealed seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) of 0.73% in May–June 2020 and 7.1% in August–September 2020. A third serosurvey was conducted between December 2020 and January 2021 to estimate the seroprevalence of SARS-CoV-2 infection among the general population and healthcare workers (HCWs) in India. Methods: The third serosurvey was conducted in the same 70 districts as the first and second serosurveys. For each district, at least 400 individuals aged ≥10 years from the general population and 100 HCWs from subdistrict-level health facilities were enrolled. Serum samples from the general population were tested for the presence of immunoglobulin G (IgG) antibodies against the nucleocapsid (N) and spike (S1-RBD) proteins of SARS-CoV-2, whereas serum samples from HCWs were tested for anti-S1-RBD. Weighted seroprevalence adjusted for assay characteristics was estimated. Results: Of the 28,598 serum samples from the general population, 4585 (16%) had IgG antibodies against the N protein, 6647 (23.2%) had IgG antibodies against the S1-RBD protein, and 7436 (26%) had IgG antibodies against either the N protein or the S1-RBD protein. Weighted and assay-characteristic-adjusted seroprevalence against either of the antibodies was 24.1% [95% confidence interval (CI) 23.0–25.3%]. Among 7385 HCWs, the seroprevalence of anti-S1-RBD IgG antibodies was 25.6% (95% CI 23.5–27.8%). Conclusions: Nearly one in four individuals aged ≥10 years from the general population as well as HCWs in India had been exposed to SARS-CoV-2 by December 2020.