학술논문
Relationships of 18F-FDG PET with tumor microenvironment immunotypes, especially PD-L1 and CD15 expression, and prognosis in oral squamous cell carcinoma
Document Type
article
Author
Source
The Egyptian Journal of Radiology and Nuclear Medicine, Vol 54, Iss 1, Pp 1-11 (2023)
Subject
Language
English
ISSN
2090-4762
Abstract
Abstract Background The relationship between 2-[18F]-fluoro-2-deoxy-d-glucose–positron emission tomography (FDG-PET) findings and programmed death ligand-1 (PD-L1) expression has been reported in several cancers. We investigated the correlations of FDG uptake with immune cell counts, including myeloid-derived suppressor cells (MDSCs), and PD-L1 expression in the tumor microenvironment. We examined 72 patients with oral squamous cell carcinoma (OSCC) with immunohistochemistry data for PD-L1, CD8, S100A8, CD15, and CD33. We used the maximum standardized uptake value (SUVmax) to reflect FDG uptake in each patient. Results High SUVmax and high MDSC counts were associated with poor prognosis. Significantly higher SUVmax was found in patients with high PD-L1 expression and in those with a high CD15+ cell density (P = 0.03 and P = 0.02, respectively). In multiple regression analysis, the tumor size had the greatest effect on SUVmax (P