학술논문
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection
Document Type
article
Author
Chang Liu; Raksha Das; Aiste Dijokaite-Guraliuc; Daming Zhou; Alexander J. Mentzer; Piyada Supasa; Muneeswaran Selvaraj; Helen M. E. Duyvesteyn; Thomas G. Ritter; Nigel Temperton; Paul Klenerman; Susanna J. Dunachie; Neil G. Paterson; Mark A. Williams; David R. Hall; Elizabeth E. Fry; Juthathip Mongkolsapaya; Jingshan Ren; David I. Stuart; Gavin R. Screaton
Source
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Subject
Language
English
ISSN
2041-1723
Abstract
Abstract The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S) binding monoclonal antibodies (mAbs) from vaccinees who suffered vaccine break-through infections with Omicron sub lineages BA.4 or BA.5. Twenty eight potent antibodies are isolated and characterised functionally, and in some cases structurally. Since the emergence of BA.4/5, SARS-CoV-2 has continued to accrue mutations in the S protein, to understand this we characterize neutralization of a large panel of variants and demonstrate a steady attrition of neutralization by the panel of BA.4/5 mAbs culminating in total loss of function with recent XBB.1.5.70 variants containing the so-called ‘FLip’ mutations at positions 455 and 456. Interestingly, activity of some mAbs is regained on the recently reported variant BA.2.86.