학술논문
The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa
Document Type
article
Author
Se Eun Park; Duy Thanh Pham; Christine Boinett; Vanessa K. Wong; Gi Deok Pak; Ursula Panzner; Ligia Maria Cruz Espinoza; Vera von Kalckreuth; Justin Im; Heidi Schütt-Gerowitt; John A. Crump; Robert F. Breiman; Yaw Adu-Sarkodie; Ellis Owusu-Dabo; Raphaël Rakotozandrindrainy; Abdramane Bassiahi Soura; Abraham Aseffa; Nagla Gasmelseed; Karen H. Keddy; Jürgen May; Amy Gassama Sow; Peter Aaby; Holly M. Biggs; Julian T. Hertz; Joel M. Montgomery; Leonard Cosmas; Beatrice Olack; Barry Fields; Nimako Sarpong; Tsiriniaina Jean Luco Razafindrabe; Tiana Mirana Raminosoa; Leon Parfait Kabore; Emmanuel Sampo; Mekonnen Teferi; Biruk Yeshitela; Muna Ahmed El Tayeb; Arvinda Sooka; Christian G. Meyer; Ralf Krumkamp; Denise Myriam Dekker; Anna Jaeger; Sven Poppert; Adama Tall; Aissatou Niang; Morten Bjerregaard-Andersen; Sandra Valborg Løfberg; Hye Jin Seo; Hyon Jin Jeon; Jessica Fung Deerin; Jinkyung Park; Frank Konings; Mohammad Ali; John D. Clemens; Peter Hughes; Juliet Nsimire Sendagala; Tobias Vudriko; Robert Downing; Usman N. Ikumapayi; Grant A. Mackenzie; Stephen Obaro; Silvia Argimon; David M. Aanensen; Andrew Page; Jacqueline A. Keane; Sebastian Duchene; Zoe Dyson; Kathryn E. Holt; Gordon Dougan; Florian Marks; Stephen Baker
Source
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Typhoid fever is caused by the bacterium Salmonella Typhi. Here, Park et al. analyse the genomes of 249 S. Typhi isolates from 11 sub-Saharan African countries, identifying genes and plasmids associated with antibiotic resistance and showing that multi-drug resistance is highly pervasive in sub-Saharan Africa.