학술논문

Emerging theragnostic radionuclide applications for hepatocellular carcinoma
Document Type
article
Source
Frontiers in Nuclear Medicine, Vol 3 (2023)
Subject
transarterial radionuclide therapy
radioembolization
hepatocellular carcinoma
prostate specific membrane antigen
fibroblast activation protein inhibitors
lipiodol
Medical physics. Medical radiology. Nuclear medicine
R895-920
Language
English
ISSN
2673-8880
Abstract
Hepatocellular carcinoma (HCC) is a major global health problem. Theragnostic is a term that refers to the integration of diagnostic and therapeutic modalities into a single system for personalized medicine. Theragnostic care in HCC involves the use of imaging techniques to diagnose the cancer and assess its characteristics, such as size, location, and extent of spread. Theragnostics involves the use of molecular and genetic tests to identify specific biomarkers that can help guide treatment decisions and, post-treatment, assess the dosimetry and localization of the treatment, thus guiding future treatment. This can be done through either positron emission tomography (PET) scanning or single photon emission tomography (SPECT) using radiolabeled tracers that target specific molecules expressed by HCC cells or radioembolization. This technique can help identify the location and extent of the cancer, as well as provide information on the tumor's metabolic activity and blood supply. In summary, theragnostics is an emerging field that holds promise for improving the diagnosis and treatment of HCC. By combining diagnostic and therapeutic modalities into a single system, theragnostics can help guide personalized treatment decisions and improve patient outcomes.