학술논문
Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling
Document Type
article
Author
Source
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Prenatal exposure to environmental stressors is known to impair cortical development. Here the authors show that upon exposure to stressors, the activation of Hsf1-Hsp signalling is highly variable among cells in the embryonic cortex of mice, and either too much or too little activation can result in defects in cortical development.