학술논문
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice
Document Type
article
Author
Stephanie J. Alexopoulos; Sing-Young Chen; Amanda E. Brandon; Joseph M. Salamoun; Frances L. Byrne; Christopher J. Garcia; Martina Beretta; Ellen M. Olzomer; Divya P. Shah; Ashleigh M. Philp; Stefan R. Hargett; Robert T. Lawrence; Brendan Lee; James Sligar; Pascal Carrive; Simon P. Tucker; Andrew Philp; Carolin Lackner; Nigel Turner; Gregory J. Cooney; Webster L. Santos; Kyle L. Hoehn
Source
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Obesity is a global pandemic with limited treatment options. Here, the authors show evidence in mice that the mitochondrial uncoupler BAM15 effectively induces fat loss without affecting food intake or compromising lean body mass.