학술논문
Salivary levels of disease-related biomarkers in the early stages of Parkinson’s and Alzheimer’s disease: A cross-sectional study
Document Type
article
Author
Source
IBRO Neuroscience Reports, Vol 14, Iss , Pp 285-292 (2023)
Subject
Language
English
ISSN
2667-2421
Abstract
Introduction: Finding a non-invasive and repeatable tool has been recommended to make an accurate diagnosis of Alzheimer’s disease (AD) and Parkinson’s disease (PD). Methods: 70 volunteers participated in three groups: 24 with mild dementia of AD, 24 in the first and second stages of PD, and 22 healthy controls. After valuing the scores of cognitive tests, the salivary levels of phosphorylated tau (p-tau), total alpha-synuclein (α-syn), and beta-amyloid 1–42 (Aβ) proteins have been evaluated. Finally, the cutoff points, receiver operating characteristic (ROC), sensitivity, and specificity have been calculated to find accurate and detectable biomarkers. Results: Findings showed that the salivary level of Aβ was higher in both PD (p