학술논문
Centromeric AA motif in KIR as an optimal surrogate marker for precision definition of alloimmune reproductive failure
Document Type
article
Author
Raquel Gil Laborda; Edgard Rodríguez de Frías; Nabil Subhi-Issa; Elena Carrillo de Albornoz; Elena Meliá; Marcos Órdenes; Victoria Verdú; Juan Vidal; Esther Suárez; Isabel Santillán; Daniel Ordóñez; David Pintado-Vera; Victoria González Villafáñez; Ángel Lorenzo; Manuel Fariñas; Mario Rodríguez-Paíno; María Núñez Beltrán; Áurea García Segovia; Ainhoa del Olmo; Fernando Martín Cañadas; Rosa Daurelio; Alfonso de la Fuente; José Manuel González Casbas; Vega Cabezuelo; Francisco Ros Berruezo; Miguel Ángel Moreno Hidalgo; Silvia Iniesta; Beatriz Bueno; Álvaro Martínez Acera; Alexandra Izquierdo; José Luis Vicario; Miguel Fernández-Arquero; Silvia Sánchez-Ramón
Source
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Throughout pregnancy, the decidua is predominantly populated by NK lymphocytes expressing Killer immunoglobulin-like receptors (KIR) that recognize human leukocyte antigen-C (HLA-C) ligands from trophoblast cells. This study aims to investigate the association of KIR-HLA-C phenotypes in couples facing infertility, particularly recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF), in comparison to a reference population and fertile controls. This observational, non-interventional retrospective case–control study included patients consecutively referred to our Reproductive Immunology Unit from 2015 to 2019. We analyzed the frequencies of KIR and HLA-C genes. As control groups, we analyzed a reference Spanish population for KIR analysis and 29 fertile controls and their male partners for KIR and HLA-C combinations. We studied 397 consecutively referred women with infertility and their male partners. Among women with unexplained RPL (133 women) and RIF (176 women), the centromeric (cen)AA KIR genotype was significantly more prevalent compared to the reference Spanish population (p = 0.001 and 0.02, respectively). Furthermore, cenAA was associated with a 1.51-fold risk of RPL and a 1.2-fold risk of RIF. Conversely, the presence of BB KIR showed a lower risk of reproductive failure compared to non-BB KIR (OR: 0.12, p