학술논문
Detection of SARS-CoV-2 RNA in serum is associated with increased mortality risk in hospitalized COVID-19 patients
Document Type
article
Author
Diego A. Rodríguez-Serrano; Emilia Roy-Vallejo; Nelly D. Zurita Cruz; Alexandra Martín Ramírez; Sebastián C. Rodríguez-García; Nuria Arevalillo-Fernández; José María Galván-Román; Leticia Fontán García-Rodrigo; Lorena Vega-Piris; Marta Chicot Llano; David Arribas Méndez; Begoña González de Marcos; Julia Hernando Santos; Ana Sánchez Azofra; Elena Ávalos Pérez-Urria; Pablo Rodriguez-Cortes; Laura Esparcia; Ana Marcos-Jimenez; Santiago Sánchez-Alonso; Irene Llorente; Joan Soriano; Carmen Suárez Fernández; Rosario García-Vicuña; Julio Ancochea; Jesús Sanz; Cecilia Muñoz-Calleja; Rafael de la Cámara; Alfonso Canabal Berlanga; Isidoro González-Álvaro; Laura Cardeñoso; the REINMUN-COVID Group
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract COVID-19 has overloaded national health services worldwide. Thus, early identification of patients at risk of poor outcomes is critical. Our objective was to analyse SARS-CoV-2 RNA detection in serum as a severity biomarker in COVID-19. Retrospective observational study including 193 patients admitted for COVID-19. Detection of SARS-CoV-2 RNA in serum (viremia) was performed with samples collected at 48–72 h of admission by two techniques from Roche and Thermo Fischer Scientific (TFS). Main outcome variables were mortality and need for ICU admission during hospitalization for COVID-19. Viremia was detected in 50–60% of patients depending on technique. The correlation of Ct in serum between both techniques was good (intraclass correlation coefficient: 0.612; p