학술논문
Depressive Symptoms, Antidepressants, and Clinical Outcomes in Chronic Kidney Disease: Findings from the CRIC Study
Document Type
article
Author
Rosalba Hernandez; Dawei Xie; Xue Wang; Neil Jordan; Ana C. Ricardo; Amanda H. Anderson; Clarissa J. Diamantidis; John W. Kusek; Kristine Yaffe; James P. Lash; Michael J. Fischer; Lawrence J. Appel, MD, MPH; Jing Chen, MD, MMSc, MSc; Debbie L. Cohen, MD; Harold I. Feldman, MD, MSCE; Alan S. Go, MD; Robert G. Nelson, MD, PhD, MS; Mahboob Rahman, MD; Panduranga S. Rao, MD; Vallabh O. Shah, PhD, MS; Mark L. Unruh, MD, MS
Source
Kidney Medicine, Vol 6, Iss 4, Pp 100790- (2024)
Subject
Language
English
ISSN
2590-0595
Abstract
Rationale & Objective: The extent to which depression affects the progression of chronic kidney disease (CKD) and leads to adverse clinical outcomes remains inadequately understood. We examined the association of depressive symptoms (DS) and antidepressant medication use on clinical outcomes in 4,839 adults with nondialysis CKD. Study Design: Observational cohort study. Setting and Participants: Adults with mild to moderate CKD who participated in the multicenter Chronic Renal Insufficiency Cohort Study (CRIC). Exposure: The Beck Depression Inventory (BDI) was used to quantify DS. Antidepressant use was identified from medication bottles and prescription lists. Individual effects of DS and antidepressants were examined along with categorization as follows: (1) BDI