학술논문
Childhood growth during recovery from acute illness in Africa and South Asia: a secondary analysis of the childhood acute illness and nutrition (CHAIN) prospective cohortResearch in context
Document Type
article
Author
Celine Bourdon; Abdoulaye Hama Diallo; Abu Sadat Mohammad Sayeem Bin Shahid; Md Alfazal Khan; Ali Faisal Saleem; Benson O. Singa; Blaise Siézanga Gnoumou; Caroline Tigoi; Catherine Achieng Otieno; Chrisantus Odhiambo Oduol; Christina L. Lancioni; Christine Manyasi; Christine J. McGrath; Christopher Maronga; Christopher Lwanga; Daniella Brals; Dilruba Ahmed; Dinesh Mondal; Donna M. Denno; Dorothy I. Mangale; Emmanuel Chimwezi; Emmie Mbale; Ezekiel Mupere; Gazi Md Salauddin Mamun; Issaka Ouédraogo; James A. Berkley; James M. Njunge; Jenala Njirammadzi; John Mukisa; Johnstone Thitiri; Judd L. Walson; Julie Jemutai; Kirkby D. Tickell; Lubaba Shahrin; Macpherson Mallewa; Md Iqbal Hossain; Mohammod Jobayer Chisti; Molline Timbwa; Moses Mburu; Moses M. Ngari; Narshion Ngao; Peace Aber; Philliness Prisca Harawa; Priya Sukhtankar; Robert H.J. Bandsma; Roseline Maïmouna Bamouni; Sassy Molyneux; Shalton Mwaringa; Shamsun Nahar Shaima; Syed Asad Ali; Syeda Momena Afsana; Sayera Banu; Tahmeed Ahmed; Wieger P. Voskuijl; Zaubina Kazi
Source
EClinicalMedicine, Vol 70, Iss , Pp 102530- (2024)
Subject
Language
English
ISSN
2589-5370
Abstract
Summary: Background: Growth faltering is well-recognized during acute childhood illness and growth acceleration during convalescence, with or without nutritional therapy, may occur. However, there are limited recent data on growth after hospitalization in low- and middle-income countries. Methods: We evaluated growth following hospitalization among children aged 2–23 months in sub-Saharan Africa and South Asia. Between November 2016 and January 2019, children were recruited at hospital admission and classified as: not-wasted (NW), moderately-wasted (MW), severely-wasted (SW), or having nutritional oedema (NO). We describe earlier (discharge to 45-days) and later (45- to 180-days) changes in length-for-age [LAZ], weight-for-age [WAZ], mid-upper arm circumference [MUACZ], weight-for-length [WLZ] z-scores, and clinical, nutritional, and socioeconomic correlates. Findings: We included 2472 children who survived to 180-days post-discharge: NW, 960 (39%); MW, 572 (23%); SW, 682 (28%); and NO, 258 (10%). During 180-days, LAZ decreased in NW (−0.27 [−0.36, −0.19]) and MW (−0.23 [−0.34, −0.11]). However, all groups increased WAZ (NW, 0.21 [95% CI: 0.11, 0.32]; MW, 0.57 [0.44, 0.71]; SW, 1.0 [0.88, 1.1] and NO, 1.3 [1.1, 1.5]) with greatest gains in the first 45-days. Of children underweight (