학술논문
Landscape of alcohol-related hepatocellular carcinoma in the last 15 years highlights the need to expand surveillance programs
Document Type
article
Author
Nicola Reggidori; Laura Bucci; Valentina Santi; Benedetta Stefanini; Lorenzo Lani; Davide Rampoldi; Giorgia Ghittoni; Fabio Farinati; Alberto Masotto; Bernardo Stefanini; Andrea Mega; Elisabetta Biasini; Francesco Giuseppe Foschi; Gianluca Svegliati-Baroni; Angelo Sangiovanni; Claudia Campani; Giovanni Raimondo; Gianpaolo Vidili; Antonio Gasbarrini; Ciro Celsa; Mariella Di Marco; Edoardo G. Giannini; Rodolfo Sacco; Maurizia Rossana Brunetto; Francesco Azzaroli; Donatella Magalotti; Filomena Morisco; Gian Ludovico Rapaccini; Gerardo Nardone; Alessandro Vitale; Franco Trevisani; Maurizio Biselli; Paolo Caraceni; Annagiulia Gramenzi; Francesca Benevento; Alessandro Granito; Luca Muratori; Fabio Piscaglia; Francesco Tovoli; Gloria Allegrini; Calogero Cammà; Giuseppe Cabibbo; Carmelo Marco Giacchetto; Paolo Giuffrida; Maria Vittoria Grassini; Mauro Grova; Gabriele Rancatore; Caterina Stornello; Valentina Adotti; Tancredi Li Cavoli; Fabio Marra; Martina Rosi; Vittoria Bevilacqua; Alberto Borghi; Lucia Napoli; Fabio Conti; G.L. Frassineti; Maria Teresa Migliano; Nicoletta de Matthaeis; Francesca Romana Ponziani; Gabriele Missale; Andrea Olivani; Mario Capasso; Valentina Cossiga; Maria Guarino; Ester Marina Cela; Antonio Facciorusso; Camilla Graziosi; Valentina Lauria; Giorgio Pelecca; Marta Schirripa; Fabrizio Chegai; Armando Raso; Alessio Bozzi; Maria Stella Franzè; Carlo Saitta; Assunta Sauchella; Elton Dajti; Federico Ravaioli; Maria Corina Plaz Torres; Giulia Pieri; Filippo Oliveri; Gabriele Ricco; Veronica Romagnoli; Alessandro Inno; Fabiana Marchetti; Pietro Coccoli; Antonio Malerba; Alberta Cappelli; Rita Golfieri; Cristina Mosconi; Matteo Renzulli
Source
JHEP Reports, Vol 5, Iss 8, Pp 100784- (2023)
Subject
Language
English
ISSN
2589-5559
Abstract
Background & Aims: Alcohol abuse and metabolic disorders are leading causes of hepatocellular carcinoma (HCC) worldwide. Alcohol-related aetiology is associated with a worse prognosis compared with viral agents, because of the lower percentage of patients diagnosed with HCC under routine surveillance and a higher burden of comorbidity in alcohol abusers. This study aimed to describe the evolving clinical scenario of alcohol-related HCC over 15 years (2006–2020) in Italy. Methods: Data from the Italian Liver Cancer (ITA.LI.CA) registry were used: 1,391 patients were allocated to three groups based on the year of HCC diagnosis (2006–2010; 2011–2015; 2016–2020). Patient characteristics, HCC treatment, and overall survival were compared among groups. Survival predictors were also investigated. Results: Approximately 80% of alcohol-related HCCs were classified as cases of metabolic dysfunction-associated fatty liver disease. Throughout the quinquennia,