학술논문
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
Document Type
article
Author
Lorna B. Jarvis; Daniel B. Rainbow; Valerie Coppard; Sarah K. Howlett; Zoya Georgieva; Jessica L. Davies; Harpreet Kaur Mullay; Joanna Hester; Tom Ashmore; Aletta Van Den Bosch; James T. Grist; Alasdair J. Coles; Hani S. Mousa; Stefano Pluchino; Krishnaa T. Mahbubani; Julian L. Griffin; Kourosh Saeb-Parsy; Fadi Issa; Luca Peruzzotti-Jametti; Linda S. Wicker; Joanne L. Jones
Source
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Jarvis et al demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A)-driven acquisition of CD73 expression, which along with CD39, enables expanded Tregs to convert ATP to immunosuppressive adenosine. Given this, the data suggests that Treg expansion protocols should be optimised for CD39/CD73 co-expression to enhance therapeutic potential.