학술논문
Sleep apnoea is a risk factor for severe COVID-19
Document Type
article
Author
Riitta Kaarteenaho; Nina Hautala; Athena Matakidou; Jaakko Kaprio; Ying Wu; Kai Kaarniranta; Peeter Karihtala; Kari Pulkki; Wei Zhou; Caroline Fox; Jussi Pihlajamäki; Apinya Lertratanakul; Juha Paloneva; Johannes Kettunen; Marita Kalaoja; Markus Perola; Veikko Salomaa; Hilkka Soininen; Mika Kähönen; Hao Chen; Andrey Loboda; Soumitra Ghosh; Anders Mälarstig; Markku Laakso; Marja Luodonpää; Markus Juonala; Xing Chen; Marika Crohns; Juhani Junttila; Sirkku Peltonen; Keith Usiskin; Juha Sinisalo; Aarno Palotie; Samuli Ripatti; Oili Kaipiainen-Seppänen; Aki Havulinna; Satu Strausz; Tuomo Kiiskinen; Martin Broberg; Sanni Ruotsalainen; Jukka Koskela; Adel Bachour; Tuula Palotie; Hanna M. Ollila; Mark Daly; Howard Jacob; Heiko Runz; Sally John; Robert Plenge; Mark McCarthy; Julie Hunkapiller; Meg Ehm; Dawn Waterworth; Kathy Klinger; Kathy Call; Tomi Mäkelä; Petri Virolainen; Terhi Kilpi; Jukka Partanen; Anne Pitkäranta; Seppo Vainio; Kimmo Savinainen; Veli-Matti Kosma; Urho Kujala; Outi Tuovila; Minna Hendolin; Raimo Pakkanen; Jeff Waring; States Bridget Riley-Gillis; Jimmy Liu; Shameek Biswas; Dorothee Diogo; Anders Pfizer; Catherine Marshall; Xinli Hu; Matthias Gossel; Johanna Schleutker; Mikko Arvas; Olli Carpen; Reetta Hinttala; Reijo Laaksonen; Arto Mannermaa; Valtteri Julkunen; Anne Remes; Reetta Kälviäinen; Mikko Hiltunen; Jukka Peltola; Pentti Tienari; Juha Rinne; Adam Ziemann; Jeffrey Waring; Sahar Esmaeeli; Nizar Smaoui; Anne Lehtonen; Susan Eaton; Sanni Lahdenperä; John Michon; Geoff Kerchner; Natalie Bowers; Edmond Teng; John Merck; Vinay Mehta; Padhraig Gormley; Kari Linden; Christopher Whelan; Fanli Xu; David Pulford; Martti Färkkilä; Sampsa Pikkarainen; Airi Jussila; Timo Blomster; Mikko Kiviniemi; Markku Voutilainen; Bob Georgantas; Graham Heap; Fedik Rahimov; Joseph Maranville; Tim Lu; Danny Oh; Kirsi Kalpala; Melissa Miller; Linda McCarthy; Kari Eklund; Antti Palomäki; Pia Isomäki; Laura Pirilä; Johanna Huhtakangas; David Close; Marla Hochfeld; Nan Bing; Jorge Esparza Gordillo; Nina Mars; Tarja Laitinen; Margit Pelkonen; Paula Kauppi; Hannu Kankaanranta; Terttu Harju; Steven GreenbergCelgene; Hubert Chen; Jo Betts; Teemu Niiranen; Kaj Metsärinne; Marja-Riitta Taskinen; Tiinamaija Tuomi; Jari Laukkanen; Andrew Peterson Ben Challis; Audrey Chu; Jaakko Parkkinen; Anthony Muslin; Heikki Joensuu; Tuomo Meretoja; Lauri Aaltonen; Annika Auranen; Saila Kauppila; Päivi Auvinen; Klaus Elenius; Relja Popovic; Bridget Riley-Gillis; Jennifer Schutzman; Aparna Chhibber; Heli Lehtonen; Stefan McDonough; Diptee Kulkarni; Joni Turunen; Terhi Ollila; Sanna Seitsonen; Hannu Uusitalo; Vesa Aaltonen; Hannele Uusitalo-Järvinen; Erich Strauss; Anna Podgornaia; Joshua Hoffman; Kaisa Tasanen; Laura Huilaja; Katariina Hannula-Jouppi; Teea Salmi; Leena Koulu; Ilkka Harvima; David Choy; Anu Jalanko; Risto Kajanne; Ulrike Lyhs; Mari Kaunisto; Justin Davis; Danjuma Quarless; Slavé Petrovski; Chia-Yen Chen; Paola Bronson; Robert Yang; Diana Chang; Tushar Bhangale; Emily Holzinger; Xulong Wang; Åsa Hedman; Kirsi Auro; Clarence Wang; Ethan Xu; Franck Auge; Clement Chatelain; Mitja Kurki; Juha Karjalainen; Kimmo Palin; Priit Palta; Pietro Della; Susanna Lemmelä; Manuel Rivas; Jarmo Harju; Arto Lehisto; Andrea Ganna; Vincent Llorens; Antti Karlsson; Kati Kristiansson; Kati Hyvärinen; Jarmo Ritari; Tiina Wahlfors; Miika Koskinen; Katri Pylkäs; Minna Karjalainen; Tuomo Mantere; Eeva Kangasniemi; Sami Heikkinen; Eija Laakkonen; Juha Kononen; Anu Loukola; Päivi Laiho; Tuuli Sistonen; Essi Kaiharju; Markku Laukkanen; Elina Järvensivu; Sini Lähteenmäki; Lotta Männikkö; Regis Wong; Hannele Mattsson; Tero Hiekkalinna; Manuel Jiménez; Kati Donner; Kalle Pärn; Javier Nunez-Fontarnau; Elina Kilpeläinen; Timo Sipilä; Georg Brein; Alexander Dada; Ghazal Awaisa; Anastasia Shcherban; Tuomas Sipilä; Hannele Laivuori; Harri Siirtola; Javier Tabuenca; Lila Kallio; Sirpa Soini; Kimmo Pitkänen; Teijo Kuopio
Source
BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)
Subject
Language
English
ISSN
2052-4439
Abstract
Background Obstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19.We aimed to study if OSA is an independent risk factor for COVID-19 infection or for severe COVID-19.Methods OSA diagnosis and COVID-19 infection were extracted from the hospital discharge, causes of death and infectious diseases registries in individuals who participated in the FinnGen study (n=260 405). Severe COVID-19 was defined as COVID-19 requiring hospitalisation. Multivariate logistic regression model was used to examine association. Comorbidities for either COVID-19 or OSA were selected as covariates. We performed a meta-analysis with previous studies.Results We identified 445 individuals with COVID-19, and 38 (8.5%) of them with OSA of whom 19 out of 91 (20.9%) were hospitalised. OSA associated with COVID-19 hospitalisation independent from age, sex, BMI and comorbidities (p-unadjusted=5.13×10−5, OR-adjusted=2.93 (95% CI 1.02 to 8.39), p-adjusted=0.045). OSA was not associated with the risk of contracting COVID-19 (p=0.25). A meta-analysis of OSA and severe COVID-19 showed association across 15 835 COVID-19 positive controls, and n=1294 patients with OSA with severe COVID-19 (OR=2.37 (95% 1.14 to 4.95), p=0.021).Conclusion Risk for contracting COVID-19 was the same for patients with OSA and those without OSA. In contrast, among COVID-19 positive patients, OSA was associated with higher risk for hospitalisation. Our findings are in line with earlier works and suggest OSA as an independent risk factor for severe COVID-19.