학술논문
Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling
Document Type
article
Author
Georgi Apriamashvili; David W. Vredevoogd; Oscar Krijgsman; Onno B. Bleijerveld; Maarten A. Ligtenberg; Beaunelle de Bruijn; Julia Boshuizen; Joleen J. H. Traets; Daniela D’Empaire Altimari; Alex van Vliet; Chun-Pu Lin; Nils L. Visser; James D. Londino; Rebekah Sanchez-Hodge; Leah E. Oswalt; Selin Altinok; Jonathan C. Schisler; Maarten Altelaar; Daniel S. Peeper
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The IFNγ response pathway is associated with response to immunotherapy in cancer. Here the authors show that high levels of the IFNγ-receptor (IFNγ-R1) affect the outcome of immunotherapy in a context-dependent fashion and identify the E3 ubiquitin ligase STUB1 as a negative regulator of IFNγ-R1/JAK1 expression in cancer cells.