학술논문
A tunable dual-input system for on-demand dynamic gene expression regulation
Document Type
article
Author
Source
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Cellular systems have numerous mechanisms to control gene expression. Here the authors build a Tet-On system with conditional destablising elements to regulate gene expression and protein stability, allowing fine modulation of mESC signalling pathways.