학술논문
Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysisResearch in context
Document Type
article
Author
Miquel Àngel Sastre-Femenia; Almudena Fernández-Muñoz; María Antonia Gomis-Font; Biel Taltavull; Carla López-Causapé; Jorge Arca-Suárez; Luis Martínez-Martínez; Rafael Cantón; Nieves Larrosa; Jesús Oteo-Iglesias; Laura Zamorano; Antonio Oliver; Fátima Galán-Sánchez; Irene Gracia-Ahufinger; Carmen Liébana-Martos; Carolina Roldán; Juan Manuel Sánchez-Calvo; Encarnación Clavijo; Laura Mora-Navas; Javier Aznar; José Antonio Lepe; Ángel Rodríguez-Villodres; Esther Recacha; Francisco Javier Casas-Círia; Carmen Martínez-Rubio; Marco Antonio Sempere-Alcocer; Lina Martín-Hita; Cristina Seral; Ana Isabel López-Calleja; Carmen Aspiroz; Marisa Monforte; Pedro de la Iglesia-Martínez; Gemma Jimenez-Guerra; Elena Riera-Pérez; Carmen Collado; Carmen Gallegos; Xavier Mulet; Miquel Àngel Sastre-Femenía; María Siller-Ruiz; Jorge Calvo; Dolores Quesada; Jun Hao Wang; Cristina Pitart; Francesc Marco; Nuria Prim; Juan Pablo Horcajada; Eduardo Padilla; Ester Del Barrio-Tofiño; Belen Viñado-Pérez; Fe Tubau; Silvia Capilla; Antonio Casabella; Mar Olga Pérez-Moreno; Emma Padilla; Mónica Ballestero; Alba Rivera; Ferrán Navarro; Fréderic Gómez-Bertomeu; Sergio Pardo-Granell; Ester Picó-Plana; Dolores Guerrero; Carolina Sarvisé-Buil; Alba Belles-Belles; Marta Fernández-Esgueva; María del Pilar Ortega-Lafont; Inmaculada García; Noelia Arenal-Andrés; Susana Hernando-Real; Rosario Ibáñez; Jesús Martínez; Federico Becerra; Carmen Aldea-Mansilla; Asmaa Alaoui-Sosse; José Carlos González; Julia Guzman-Puche; Miguel Ángel Blázquez-Andrada; Nora Mariela Martínez-Ramírez; Alicia Beteta; Bárbara Gomila-Sard; Salvador Giner Almaraz; Eugenio Garduño; Pedro Miguel Juiz-González; Javier Alba; Pilar Alonso; Ana Isabel Rodríguez; María Isabel Paz-Vidal; Marta García-Campello; Pablo Camacho; María de los Ángeles Pallarés; María Luisa Pérez del Molino; Amparo Coira; Gema Barbeito; Anniris Rincón; Francisco José Vasallo-Vidal; Laura Alonso-Acero; Laura Iglesias-Llorente; Ana Bordes-Benites; Laura Florén-Zabala; José Manuel Azcona; Carla Andrea Alonso; Yolanda Sáenz; Marta Lamata-Subero; David Molina; Ana González-Torralba; Jennifer Villa; Esther Viedma; Emilia Cercenado; Teresa Alarcón; Paula Vargas; María Díez; Patricia Ruiz; María Isabel Sánchez-Romero; Felipe Pérez-García; Genoveva Yagüe-Guirao; Amaia Concepción Oteiza; José Leiva; María Eugenia Portillo; Andrés Canut-Blasco; Matxalen Vidal; Iker Alonso; Maider Zuriarrain; José Luis Barrios-Andrés
Source
The Lancet Regional Health. Europe, Vol 34, Iss , Pp 100736- (2023)
Subject
Language
English
ISSN
2666-7762
Abstract
Summary: Background: Pseudomonas aeruginosa healthcare-associated infections are one of the top antimicrobial resistance threats world-wide. In order to analyze the current trends, we performed a Spanish nation-wide high-resolution analysis of the susceptibility profiles, the genomic epidemiology and the resistome of P. aeruginosa over a five-year time lapse. Methods: A total of 3.180 nonduplicated P. aeruginosa clinical isolates from two Spanish nation-wide surveys performed in October 2017 and 2022 were analyzed. MICs of 13 antipseudomonals were determined by ISO-EUCAST. Multidrug resistance (MDR)/extensively drug resistance (XDR)/difficult to treat resistance (DTR)/pandrug resistance (PDR) profiles were defined following established criteria. All XDR/DTR isolates were subjected to whole genome sequencing (WGS). Findings: A decrease in resistance to all tested antibiotics, including older and newer antimicrobials, was observed in 2022 vs 2017. Likewise, a major reduction of XDR (15.2% vs 5.9%) and DTR (4.2 vs 2.1%) profiles was evidenced, and even more patent among ICU isolates [XDR (26.0% vs 6.0%) and DTR (8.9% vs 2.6%)] (p