학술논문
Heterogenous transmission and seroprevalence of SARS-CoV-2 in two demographically diverse populations with low vaccination uptake in Kenya, March and June 2021 [version 2; peer review: 1 approved, 2 approved with reservations]
Document Type
article
Author
Peninah Munyua; Terrence Q. Lo; Amy Herman-Roloff; Patrick K. Munywoki; Carolyne Nasimiyu; Godfrey Bigogo; George Aol; Alice Ouma; Samuel Rono; Clifford O. Oduor; George O. Agogo; Joshua Auko; Dismas Oketch; Ruth Njoroge; Victor W. Odeyo; Dennis Odhiambo; Clayton Onyango; Gilbert Kikwai; Elizabeth Hunsperger; Bonventure Juma; Caroline Apondi Ochieng; Shirley Lidechi
Source
Gates Open Research, Vol 7 (2023)
Subject
Language
English
ISSN
2572-4754
Abstract
Background: SARS-CoV-2 has extensively spread in cities and rural communities, and studies are needed to quantify exposure in the population. We report seroprevalence of SARS-CoV-2 in two well-characterized populations in Kenya at two time points. These data inform the design and delivery of public health mitigation measures. Methods: Leveraging on existing population based infectious disease surveillance (PBIDS) in two demographically diverse settings, a rural site in western Kenya in Asembo, Siaya County, and an urban informal settlement in Kibera, Nairobi County, we set up a longitudinal cohort of randomly selected households with serial sampling of all consenting household members in March and June 2021. Both sites included 1,794 and 1,638 participants in March and June 2021, respectively. Individual seroprevalence of SARS-CoV-2 antibodies was expressed as a percentage of the seropositive among the individuals tested, accounting for household clustering and weighted by the PBIDS age and sex distribution. Results: Overall weighted individual seroprevalence increased from 56.2% (95%CI: 52.1, 60.2%) in March 2021 to 63.9% (95%CI: 59.5, 68.0%) in June 2021 in Kibera. For Asembo, the seroprevalence almost doubled from 26.0% (95%CI: 22.4, 30.0%) in March 2021 to 48.7% (95%CI: 44.3, 53.2%) in July 2021. Seroprevalence was highly heterogeneous by age and geography in these populations—higher seroprevalence was observed in the urban informal settlement (compared to the rural setting), and children aged